He collaborated with David Byrne, formerly of Talking Heads, on My Life in the Bush of Ghosts which was one of the first albums not in the rap or hip hop genres to extensively feature sampling. Eno collaborated with David Bowie as a writer and musician on Bowie's influential "Berlin trilogy" of albums, Low, Heroes and Lodger, on Bowie's later album 1. Outside, and on the song "I'm Afraid of Americans". Eno has also collaborated with Robert Fripp of King Crimson, Robert Wyatt on his Shleep CD, with Jon Hassell and with the German duo Cluster.
In 1975, Eno released Discreet Music. The second side consisted had several versions of Pachelbel's canon to which various algorithmic transformations have been applied, rendering it almost unrecognisable.
Eno has acted as a producer for a number of bands, including U2 and James. He won the best producer award at the 1994 and 1996 BRIT awards. He is an innovator across many fields of music and recently he has collaborated on the development of the Koan algorithmic music generator. He has also been involved in the field of visual arts. The band A Certain Ratio took their name from the lyrics of Eno's song "The True Wheel" (on Taking Tiger Mountain (By Strategy)).
In 1996 Brian Eno, and others, started the Long Now Foundation to educate the public into thinking about the very long term future of society. Brian Eno is also a columnist for the British newspaper, The Observer.
His younger brother, Roger Eno is also an ambient musician.