His work has been extensively used in movie soundtracks, most notably in collaboration with Ryuichi Sakamoto and Cong Su on Bernardo Bertolucci's The Last Emperor, which won an Oscar for Best Original Score. Byrne also directed True Stories, a collage of quirky Americana, as well as the films Īle Aiye and Between the Teeth
Byrne founded Luaka Bop, a world music record label which releases the work of artists Cornershop, Os Mutantes, Los De Abajo, and others. Byrne is also a successful photographer, having shown his work in contemporary art galleries and museums around the world since the 1990s. His images are sometimes exhibited as part of sound installations. He is represented by Pace/MacGill Gallery, NYC.
For the 2001 release of Windows XP, Byrne's song Like Humans Do from the album Look Into The Eyeball was included with the Operating System, and more specifically, Windows Media Player 8. In late 2003, David Byrne released a book/DVD, called Envisioning Emotional Epistemological Information, of artwork composed entirely in Microsoft PowerPoint. It includes such images as one that depicts, according to Byrne, "Dan Rather's profile. Expanded to the nth degree. Taken to infinity. Overlayed on the back of Patrick Stewart's head."
On March 16, 2004, Byrne released his latest solo album, titled Grown Backwards, on Nonesuch. This album is most noticeable for its use of orchestral string arrangements, and even includes two operatic arias.