He initially came to prominence fronting the band Them, which he formed and with whom he had a number of chart hits. After leaving the band, he pursued a successful and idiosyncratic solo musical career. Brown-Eyed Girl is probably his best-known song. Among his other hits are Domino, Moondance, Wild Night and Tupelo Honey.
In 1990 he joined many other guests for Roger Waters' massive performance of The Wall in Berlin.